Researchers may have discovered the underlying cause of " COVID toes " , the chilblain - like inflammation and lesions report by many patients with COVID-19 .
The symptom , which has been realize from ahead of time in the COVID-19 pandemic , see patients’toes or fingersturn red or royal , often with painful bumps and now and then pus . Dermatologists who would usually see four or five patient with these kinds of lesion – commonly because of inflammation in small blood vessels during cold conditions – suddenly sawdozens in just a few week .
" This rash seems to be more common in younger the great unwashed , " the British Association of Dermatologistswrite on their web site . " It usually presents later in the transmission and may appear weeks after the oncoming of the viral infection . The fingers and toe are usually sore , but not itchy . When the rash recovers , the top layers of the hide may flake off where the purplish bumps were with big , scaly patches during the retrieval period . "
research worker look into the newfangled muckle of cases associate with COVID-19 believe that the symptom may be a result of the resistant arrangement attempting to contend off the computer virus .
In their study , published in theBritish Journal of Dermatology , researchers from the University of Paris examined 50 patients at Saint - Louis Hospital , Paris , France , from April 9 - 16 2020 . All of the patients had been referred to dermatologists with chilblain - like lesions and did n’t have a history of exchangeable problem . The study also see at 13 others who had similar wound pre - Covid , and so were unrelated to the malady .
As with every job in the TV showHouse , the problem looks like in the immune response .
" SARS - CoV-2 infection strongly triggers the expression of type I interferon ( IFN)-stimulated gene , which aid in the host ’s antiviral protection , " the teamwrite in their paper . " disease intermediate by type I IFN , such as monogenic autoinflammatory interferonopathies or lupus erythematosus , are characterized by microangiopathy leading to clinical pernio . "
basically , affected role with the pernio had sire high level of sure types of autoantibody , which the squad trust had targeted their own cell rather than the virus , cause the fervor . As well as this , patients with the condition were found to have higher level of case I interferon protein , suggest that these cytokines had a persona in the inflammation response .
The symptom , while seen commonly during earlier waves of the pandemic , hasbecome rareras new chance variable such as Delta have become more prevalent , and vaccination programs have been pitch . However , for patients that do get the symptom , this Modern study is good news show .
" The ratification of the cause will help to acquire unexampled treatments to wield it more effectively , " podiatrist Dr Ivan Bristowtold the BBC .
