Christina Applegate in ‘Dead to Me’.Photo:Saeed Adyani/Netflix

Christina Applegate in Dead to Me

Saeed Adyani/Netflix

Christina Applegatebegan experiencing the firstsymptoms of multiple sclerosiswhile filming the pilot forDead to Me, long before she was diagnosed with the disease in 2021.

During the Wednesday, Dec. 11 episode ofMeSsy, the podcast she co-hosts withJamie-Lynn Sigler, Applegate, 53, recalled falling while filming a scene of her character running across a field.

“I remember falling that day,” Applegate said in the discussion withDead to Mecreator Liz Feldman. “Hi, first sign ofMS! So, not to bring everybody down, but there it was.”

“I remember you losing your balance when we were shooting the pilot a couple of times,” Feldman, 47, told Applegate. “It was very hard to figure it out because, you know, I remember one time, it was really late at night. We’d been shooting probably 14 or 15 hours … It seemed completely reasonable that anybody would be collapsing.”

“It was MS,” Applegate said.

Christina Applegate and Jamie-Lynn Sigler.John Russo

Christina Applegate and Jamie-Lynn Sigler photographed exclusively by John Russo in the Hollywood Hills on March 6, 2024.

John Russo

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Applegate announced herMS diagnosis in August 2021, saying she was diagnosed a few months prior. However, Applegate still finished filming thethird and final seasonofDead to Me, even as her mobility declined. The progressive disease “damages the protective cover around nerves called myelin in your central nervous system. It can cause muscle weakness, vision changes, numbness and memory issues,” according to theCleveland Clinic.

“There’s no handbook for this,” Feldman said. “I can’t compare it to any experience I’ve ever gone through with a person before.”

“I could just sense A, that she was scared, and B, that something was wrong … that something in her body was not working the way that she wanted it to.”

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Later, Applegate praised Feldman and the rest of theDead to Mecrew for their understanding during production, specifically recalling how filming was once shut down a week because of her.

“That would not happen anywhere else, so my gratitude towards you guys being humans - because you should be humans and love other humans - is astounding,” Applegate said. “I can’t even tell you… That’s not the normal reaction.”

(left to right): Christina Applegate, Linda Cardellini and Liz Feldman.Getty

Christina Applegate, Linda Cardellini and creator Liz Feldman attend “Dead To Me” #NETFLIXFYSEE For Your Consideration Event at Netflix FYSEE At Raleigh Studios on June 03, 2019 in Los Angeles, California.

Getty

Dead to Mestarred Applegate andLinda Cardellinias two grieving women who bond during therapy and become intertwined, despite their very different personalities. Applegate earned Emmy nominations in 2020 and 2023 for her performance.

In December 2022,Applegate told Kelly Clarksonthat filming the final season helped her cope with her MS diagnosis.

“The beauty ofDead to Meis that it gave me almost this weird platform of dealing with it, where I didn’t have to be on all the time and I didn’t have to make all the jokes and I could fall apart in a scene,” Applegate said. “And it was, like, me. It was my soul actually falling apart, unfortunately, in front of the world, but it was cathartic in a beautiful way.”

source: people.com